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JPK NanoTracker

Nanotechnology for Life Science

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Applications examples

Analysis of protein (un)folding and function
Interaction studies of DNA/RNA, motor proteins, carbohydrates with <pN sensitivity
Molecular mechanics (pulling, stretching)
Cell membran research such as lateral organization (e.g. lipid rafts)or trans-membrane processes, trafficking
Cell-particle interaction
Diffusion mesurements
Nano-toxicity and drug delivery
Endocytosis, Phagocytosis
Cellular assembly
Local gene or drug delivery
Viral and bacterial infection
Bacterial entrance mechanism studies
And many more

NanoTracker (TM) Kinesin motility

Kinesin motility

Original quadrant photodiode deflection signal due to kinesin stepping on a microtubule filament. There are multiple kinesins bound to the 1um silica microspheres, resulting in a continuous walking. The orange line results from filtering of the raw data (green).

NanoTracker : Optical Tweezers

NanoTracker� setup on Zeiss

NanoTracker setup with syringe pumps
on Zeiss Axio Observer base

For More Information, please contact:

Sid Ragona, Ph.D.

Ragona Scientific

ph./fax (585) 249-7692

sid2006@rochester.rr.com

www.ragonascientific.com

The first commercial tweezers system to employ back focal plane tracking in X, Y and Z.

With the NanoTracker, the user can trap and track particles from several um down to 30nm with the ability to control, manipulate and observe samples from vesicles to whole cells in real time with nanometer precision.

NanoTracker technology provides precisely quantifiable and reproducible measurements of particle/ cell interactions. The system delivers precise information about single molecule mechanics and may also be used to determine mechanical characteristics such as adhesion, elasticity or stiffness on single molecules.

Key features

Real-time data - essential for living cell studies
Two full time traps and multiple shared traps
Back focal plane detection for highest 3D spatial resolution
Particle tracking in 3 dimensions.
Dual and independent beam steering in three dimensions
Force resolution of 100 fN
Temperature and perfusion flow cell accessories.
Short path length of added stability
Laser safety interlocks
100 x 100 x 100 high resolution piezo sample stage accessory.
Optical sectioning (z-stacks) of images

Additional Products offered by Ragona Scientific
NanoWizard III - JPK	NanoTracker - JPK	Force Robot 300 - JPK
CellHesion 200 - JPK	BioMAT - JPK	NanoIndentation- Micro Materials
Ozone cleaner - Bioforce	CytoEnabler - Bioforce	NanoEnabler - Bioforce
AFM Probes - CDI	TriMScope - LVBT	Top Plate - LVBT
SmartSPM 1000 - AIST-NT	OmegaScope 1000 -AIST-NT	CombiScope 1000-AIST-NT
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